Drug repurposing techniques allow existing drugs to be tested against diseases outside their initial spectrum, resulting in reduced cost and eliminating the long time-frames of new drug development.In silico drug repurposing further speeds up the process either by proposing drugs suitable to invert the Urn Necklace Gift Box transcriptomic profile o

In order Bleach to analyze the year-end water level of multi-year regulating reservoir of the cascade hydropower system, this paper studied the joint operation optimization model of cascade reservoirs and its solving method based on multi-dimensional dynamic programming, and analyzed the power generation impact factors of cascade system that contai

In this article we assess the appropriateness of the constant volatility assumption required by the Black (1976) option pricing model for options on the All Share Index future.The assessment uses similar nonparametric tests as implemented in Rubinstein for data recorded over the 1992 to 1996 period.In the nonparametric tests we focus on the examina

Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in exonic regions of unrelated genes, which in turn leads to the synthesis of polyglutamine (polyQ) proteins.PolyQ proteins are prone to aggregate and form intracellular inclusions, J

When continents collide, the arrival of positively buoyant continental crust slows down subduction.This collision often leads to the detachment of earlier subducted oceanic lithosphere, which changes the subsequent dynamics of the orogenic system.Recent studies of continental collision infer that the remaining slab may drive convergence through sla